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FACTOR VIII, ACTIVATED
Descriptors Found:
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DeCS
Descriptor
English
:
Factor VIIIa
Descriptor
Spanish
:
Factor VIIIa
Descriptor
Portuguese
:
Fator VIIIa
Synonyms
English
:
Factor VIII, Activated
Factor VIII, Thrombin-Activated
Coagulation Factor VIIIa
Tree Number:
D12.776.124.125.350.300
D23.119.350.300
Definition
English
:
Activated form of
factor VIII
. The B-domain of
factor VIII
is proteolytically cleaved by
thrombin
to form
factor VIIIa
.
Factor VIIIa
exists as a non-covalent dimer in a metal-linked (probably
calcium
) complex and functions as a cofactor in the enzymatic activation of
factor X
by
factor IXa
.
Factor VIIIa
is
similar
in structure and generation to
factor Va.
Entry Combination - descr/qualif
English
:
Factor VIIIa
/
deficiency
use
Hemophilia A
See Related
English
:
Coagulants
History Note
English
:
90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24644
Unique Identifier:
D015944
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS